Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures

Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures.

In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1) in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acet...

Pharmaceutical Cocrystals: An Overview

In the last few years, a large number of drugs have been discovered with low aqueous solubility. Among these recently discovered drugs, about 60-70% of the compounds are related to the BCS Class II (low solubility/high permeability) and IV (low solubility/ low permeability)[1,2]. Many active pharmaceutical ingredients (APIs) have not been developed in formulations due to low aqueous solubility,...

Solubility Prediction of Anthracene in Non-Aqueous Solvent Mixtures Using Jouyban-Acree Model

      A quanitative structure property relationship was proposed to calculate the binary interaction terms of the Jouyban-Acree model using solubility parameter, boiling point, vapour pressure and density of solvents. The applicability of the proposed method for reproducing solubility data of anthracene in binary solvents has been evaluated using 116 solubility data sets collected from the lite...

Pharmaceutical Sciences Seminar “pH-Dependent Solubility, Dissolution, and Stability of Ketoconazole Cocrystals” Presented by:

Poor aqueous solubility is a major challenge for the drug development process, and many strategies have been developed to combat this problem. Cocrystals have gathered much interest in the recent years, due to their ability to enhance drug solubilities by orders of magnitude. However, highly soluble cocrystals tend to undergo rapid solution mediated transformation back to less soluble drug form...

Towards more Efficient Screening of Pharmaceutical Cocrystals